詳細介紹：

學習與工作經歷

2021.06-至今 河北農業大學🙇🏿‍♂️👩🏼‍⚕️，太阳2娱乐，農藥系，“青年才俊”引進人才，校聘副教授

2019.09-2020.09 京都大學（日本），工太阳2🐒，合成&生物化學專攻，訪問學者

2015.09-2021.01  中國農業大學🧙，理太阳2， 農藥學，博士

2011.09-2015.06 河南科技太阳2🧑‍✈️，資源與環境太阳2，植物保護專業，學士

研究方向

主要從事基於計算機輔助的綠色農藥、熒光底物分子合理設計與合成評價工作。重點在計算機輔助藥物設計方法的開發及其在農藥和醫藥開發中的應用、發現新型高活性先導化合物🈷️、分子結構優化和合成等領域的研究。

科研項目

1. 國家自然科學基金青年科學項目🙂‍↔️，32102247，基於虛擬篩選—共價修飾的策略發掘新型OfChi-h抑製劑，2022.01-2024.12，30萬，在研，主持🤹🏼‍♂️；

2. 河北農業大學引進人才科研專項，YJ2021021，新型幾丁質酶抑製劑的設計合成與活性評價🦂，2021.06-2025.12，20萬🎎，在研，主持；

3. 河北省高校基本科研業務費項目🛀，KY2021066🤾🏼，基於AlphaFold 2輔助的虛擬篩選發掘新型高效的昆蟲魚尼丁受體抑製劑🏷，2021.01-2022.11，1萬，結題🦶🏿，主持；

4. 河北省重點研發計劃項目🤚，22326508D，新型昆蟲OfChi-h和OfHex1雙靶標抑製劑的設計🪣、合成及活性研究，2022-07至2024-12☝🏿，30萬🤦🏻‍♂️，在研，主持；

5. 國家重點實驗室自主研究課題，NCCIR2022ZZ-18，靶向於OfChi-h的新型綠色殺蟲劑分子的發掘👨🏽‍⚕️，2022-02至2023-09，15萬，在研，主持👨🏼‍🚒。

代表性成果🤰🏽：

1. Dong, L.; Shen, S.; Jiang, X.; Liu, Y.; Li, J.; Chen, W.; Wang, Y.; Shi, J.; Liu, J.; Ma, S., Discovery of Azo-Aminopyrimidines as Novel and Potent Chitinase O f Chi-h Inhibitors via Structure-Based Virtual Screening and Rational Lead Optimization. J Agr Food Chem 2022, 70 (38), 12203-12210.

2. Shen, S.; Ding, B.; Jiang, X.; Yang, M.; Yang, Q.; Dong, L.*, Discovery of novel inhibitors targeting nematode chitinase CeCht1: Virtual screening, biological evaluation, and molecular dynamics simulation. Frontiers in Chemistry 2022, 10.

3. Dong, L.; Zhang, J., Research progress of avermectin: A minireview based on the structural derivatization of avermectin. Advanced Agrochem 2022, 1 (2), 100-112.

4. Dong, L.; Shen, S.; Xu, Y.; Wang, L.; Yang, Q.; Zhang, J.; Lu, H., Identification of novel insect β-N-acetylhexosaminidase OfHex1 inhibitors based on virtual screening, biological evaluation, and molecular dynamics simulation. J. Biomol. Struct. Dyn. 2021, 39 (5), 1735-1743.

5. Shen, S.＃; Dong, L.＃; Chen, W.; Wu, R.; Lu, H.; Yang, Q.; Zhang, J., Synthesis, Optimization, and Evaluation of Glycosylated Naphthalimide Derivatives as Efficient and Selective Insect β-N-Acetylhexosaminidase OfHex1 Inhibitors. J Agr Food Chem 2019, 67 (22), 6387-6396.

       6. Dong, L.; Shen, S.; Lu, H.; Jin, S.; Zhang, J., Novel Glycosylated Naphthalimide-Based Activatable Fluorescent Probe: A Tool for the Assessment of Hexosaminidase Activity and Intracellular Hexosaminidase Imaging. ACS Sens 2019, 4 (5), 1222-1229.

       7. Dong, L.; Shen, S.; Chen, W.; Xu, D.; Yang, Q.; Lu, H.; Zhang, J., Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation. J Chem Inf Model 2019, 59 (10), 4374-4382.

       8. Dong, L.; Shen, S.; Xu, Y.; Wang, L.; Feng, R.; Zhang, J.; Lu, H., Computational Studies on the Potency and Selectivity of PUGNAc Derivatives Against GH3, GH20, and GH84 beta-N-acetyl-D-hexosaminidases. Front Chem 2019, 7 (235), 235.

       9. Dong, L.; Shen, S.; Chen, W.; Lu, H.; Xu, D.; Jin, S.; Yang, Q.; Zhang, J., Glycosyl triazoles as novel insect β-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations. Bioorg. Med. Chem. 2019, 27 (12), 2315-2322.

      10. Dong, L.; Feng, R.; Bi, J.; Shen, S.; Lu, H.; Zhang, J., Insight into the interaction mechanism of human SGLT2 with its inhibitors: 3D-QSAR studies, homology modeling, and molecular docking and molecular dynamics simulations. J Mol Model 2018, 24 (4), 86.

獎勵情況：

2019年博士國家獎學金🏃🏻‍♀️‍➡️，2019年北京市振興農藥事業獎